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Animals that died were submitted to necropsy and the time of their death recorded; survivors were killed on the post-operation 11th day and necropsied. All animals of group 4 survived. Os animais alcimo gay grupo 4 sobreviveram. Effects of peritoneal lavage with lidocaine on survival of rats with fecal peritonitis 1.

Animals that died were submitted to necropsy and the time of their death recorded; survivors were killed on the post-operation 11 th day and necropsied. Despite all advances in the treatment of peritonitis, no decrease in mortality from that disease occurred over the last two decades.

This mortality increases when multiple organ and systemic dysfunctions occur. Although not having a well-elucidated pathogeny, this dysfunction seems to be consequent to a complex inflammatory process. The septic response is associated with the release of anti-inflammatory and inflammatory cytokines 2,3,4followed by activation of leukocytes, complement and the coagulation cascade 5as well as antibody production and bacteria destruction by polymorphonuclear leukocytes.

Local anesthetics have shown to be efficient modulators of the inflammatory cascade in ischemia and heart 8, 9lung 10, 11 and liver reperfusion 12, They are capable of performing an anti-inflammatory action on various on cell types, including monocytes, macrophages and neutrophils Ropivacaine decreased the pulmonary inflammatory response evoked by a lipopolysaccharide in rats One percent lidocaine and 0.

Some anesthetics furthermore, presented at the laboratory level, a bactericidal effect against some bacteria 19, Based on these aspects, we questioned whether intraperitoneral application of a local anesthetic dissolved in saline, could improve the survival of animals submitted to peritonitis.

The present work was aimed at the verification of the effect on survival from fecal. Five ml of a suspension of 2g of recently defecated feces, diluted in 17ml of saline, were injected into the abdominal cavity, alcimo gay having been filtered through gauze in order to permit free passing through the interior of the needle in the direction of the cavity.

Animals were aleatorily distributed into 4 groups of 12 each as follows: 1-Controls, no therapy; 2- Drying of the abdominal cavity; 3- Peritoneal lavage with 3 ml 0.

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In groups 3 and 4 the saline solution, with or without anesthetic, was left for three min in the cavity, and carefully manipulated between the abdominal viscera to let the anesthetic establish greater contact with the peritoneum and a more efficient action.

The peritoneal fluid was then dried with gauze removing most of it, the abdominal wall sutured in two planes with "mononylon"simple sewing. On the first plane, the aponeurotic muscles and on the second, the skin were sutured. All animals were subcutaneously rehydrated with a single dose of 10 ml of 0.

Analgesia was applied by subcutaneous 0. Animals that had died, were submitted to necropsy, and the time of their death, recorded. Secretion at infection sites were collected from the abdominal cavity, for bacteriological examination. Adherences were classified into six grades according to Diogo-Filho et al 21 : grade 0- absence; grade 1- a reduced number of adherences of fibrous character, easily disintegrated by manipulation; grade 2- firm adherences resistant to manipulation, located between intestinal loops alcimo gay not involving the abdominal wall; grade 3- firm adherences, resistant to manipulation, between the abdominal wall and an abdominal organ or structure; grade 4- firm adherences, resistant to manipulation, located between the abdominal wall and more than one organ or structure; grade 5- firm adherences, resistant to manipulation, found between loops and between loops and the abdominal wall, showing an enteric fistula.

Survival frequencies were analyzed by exact Fisher test comparisons between number of survivals per group, and Kaplan Meier survival curves by the Log Rank test. The Kruskal-Wallis analysis of variance was utilized to compare body weights of the 4 animal groups.

Laparotomy performed 6 hours following abdominal puncture and injection of a suspension of the recently defecated feces, showed edema, hyperemia between loops and secretion of purulent fluid in the abdominal cavity. Proteus mirabilis, Klebsiela pneumoniae, Enterococus faecalis, Escherichia coli, Micrococus, Proteus penneri, Enterococus gallinarum, Staphylococcus sciuri, Bacillus species, Staphylococcus epidermidis, Aerococcus viridans.

Their sensitivities to antibiotics are shown on Chart 1. Rats surviving the operation were dynamic and ingested liquid food. Examination of their abdominal cavity showed 2 nd and 3 rd degree adherences between intestinal loops and the abdominal wall. Rats that died were adynamic, with piloerection, a dark halo around the alcimo gay, tachypneic and anorectic.